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Depression is real and can also be life threatening. And like Happiness, Depression or Sadness, depression has many contributing factors. Human Chemistry is very sensitive and complex. Helping

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We have learned that Thoughts can influence our Mood, and our Moods or Body can influence our Thoughts. A gut feeling that something is not right. Knowing your Baseline can help you to be more aware of any changes. Depression is more then a chemical imbalance, it's more about an information imbalance. You don't have enough information in order to accurately react to changes. And learning is the only pill that will correct this imbalance of information.

Sadness is an emotional pain associated with, or characterized by, feelings of disadvantage, loss, despair, grief, helplessness, disappointment and sorrow. An individual experiencing sadness may become quiet or lethargic, and withdraw themselves from others. An example of severe sadness is depression. Crying is often an indication of sadness.

Biology of Depression shows numerous brain areas can have altered activity in patients suffering from depression, and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes. Several theories concerning the biologically based cause of depression have been suggested over the years, including theories revolving around monoamine neurotransmitters, neuroplasticity, inflammation and the circadian rhythm.

Monoamines are neurotransmitters that include serotonin, dopamine, norepinephrine, and epinephrine. Many antidepressant drugs increase synaptic levels of the monoamine neurotransmitter, serotonin, but they may also enhance the levels of two other neurotransmitters, norepinephrine and dopamine. The observation of this efficacy led to the monoamine hypothesis of depression, which postulates that the deficit of certain neurotransmitters is responsible for the corresponding features of depression: "Norepinephrine may be related to alertness and energy as well as anxiety, attention, and interest in life; [lack of] serotonin to anxiety, obsessions, and compulsions; and dopamine to attention, motivation, pleasure, and reward, as well as interest in life." The proponents of this hypothesis recommend choosing the antidepressant with the mechanism of action impacting the most prominent symptoms. Anxious or irritable patients should be treated with SSRIs or norepinephrine reuptake inhibitors, and the ones with the loss of energy and enjoyment of life—with norepinephrine and dopamine enhancing drugs. Others have also proposed the relationship between monoamines and phenotypes such as serotonin in sleep and suicide, norepinephrine in dysphoria, fatigue, apathy, cognitive dysfunction, and dopamine in loss of motivation and psychomotor symptoms.

Major Depressive Disorder also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations. It is often accompanied by low self-esteem, loss of interest in normally enjoyable activities, low energy, and pain without a clear cause. People may also occasionally have false beliefs or see or hear things that others cannot. Some people have periods of depression separated by years in which they are normal while others nearly always have symptoms present. Major depressive disorder can negatively affect a person's personal, work, or school life, as well as sleeping, eating habits, and general health. Between 2–7% of adults with major depression die by suicide, and up to 60% of people who die by suicide had depression or another mood disorder.

Depression (mood) is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings, and sense of well-being. People with a depressed mood can feel sad, anxious, empty, hopeless, helpless, worthless, guilty, irritable, angry, ashamed, or restless. They may lose interest in activities that were once pleasurable, experience loss of appetite or overeating, have problems concentrating, remembering details or making decisions, experience relationship difficulties and may contemplate, attempt or commit suicide. Insomnia, excessive sleeping, fatigue, aches, pains, digestive problems, or reduced energy may also be present.

"You don’t drown by falling in the water. You drown by staying there."

One thought leads to another. I was thinking about an experience that I had years ago, which lead me to remember another similar experience that I had, which lead me to remember another experience that was related to the other experience that I had, and that experience was really sad, which made me feel really sad. How did I get here? Oh ya, one thought leads to another. Before it all started, I was just happy and fine. Memories. The good, the bad and the ugly. I will always back track my thoughts now, and stick with the good memories, and not let my thoughts carry me to far away to the land of bad times. Besides, thoughts that lead to other thoughts is a good thing to have, especially when you're coming up with new ideas or solving problems. But you need to be aware of Racing Thoughts, when the mind uncontrollably brings up random thoughts and memories that zoom through the mind as they jump from one to the next. If experiencing these thoughts at night when going to sleep, and suddenly awaken, you may be startled and confused by the very random and sudden nature of thoughts. It's not that you are losing control of your thoughts, it's just that you were  not aware of the fact that you were not paying attention to what you were thinking about. And when you do pay attention to what you are thinking, and focus on thoughts and ideas that are relevant and valuable, then you will become more aware and more in control of your thinking. You have to remember that the brain never stops working, but you can control the speed and the subjects when you are awake and aware. But when you're sleeping or not aware, that's when you brain does things randomly, like the dreams you have when sleeping.

Retrace your thoughts and go back over your thoughts again and reassemble them mentally. If you want to stop going down the same path, you have to understand the exact words that are causing you to turn unconsciously down a path that leads to depressing thoughts. The more times that you can catch yourself thinking these particular thoughts, the more control you will have in changing the direction of your thinking, which will help you avoid going down the same path that leads you to nowhere, except sadness.

You Are What You Think - Language Shapes your Thoughts

Reverse Placebo Effect

Intrusive Thought is an unwelcome involuntary thought, image, or unpleasant idea that may become an obsession, is upsetting or distressing, and can feel difficult to manage.

One great way to become aware of your thoughts is to focus on your breathing. Focus on breathing in and then breathing out. Then after a few moments focus on your goals, or your mantra, or things that you know are healthy or important. Then you can start your day again. If you are trying to sleep, just focus on your breathing and try not to think of anything and clear your mind, just relax and go back to sleep.

Get Unplugged (technology addiction)

Non-Physical Pain

Everyone gets depressed. But for some people depression is a serious debilitating illness. Finding the correct treatment is very difficult. But the more treatment options that you can learn about the better your chances will be in getting the right kind of help.

There are many internal factors and many external factors that need to be defined. So be very careful with assessments. Learn as much as you can about the phycology of the self and be very careful with medications, because certain drugs can make things worse.

Know your Baseline

ACT Coach App, learn how to control negative thoughts and feelings by trough awareness exercises (Free iOS)  
Depression CBT Self-Help Guide (Free App)
Mind Shift (app)

Meditation Apps

Super better tool helps illness or Injury Recovery

Support Groups (counseling)

Assessment Errors

Adolescent Depression Knowledge Questionnaire (ADKQ)
Achieving Depression Literacy

Self Directed Learning (training and learning something new)

We also know that the brain changes, and certain areas like the Hippocampus, may Shrink, which can cause a person to be emotionally sensitive and unable to control emotions. You can easily attach an Emotion to a certain thought or memory. This could trigger a depression that will last long after the thought or memory is over. So if you recognize what thought or memory triggered that depressive feeling then you could train yourself not to react in a depressive or negative way to that memory or thought in the future. This way that thought or memory will not trigger a depression because you are now aware of the negative influence of this memory, thought, or situation, and now you understand it and now you can move past it without it causing you to feel depressed anymore. This also applies to future actions or future situations that you must contend with. If you feel Anxiety or worry about future situations then you must separate these emotions from the actual information so that you can clearly understand this moment in the future.

Hormones - Microbes
Food - PH
Weather Effects
Pharmaceutical Precautions and Information

Dysthymia is a mood disorder consisting of the same cognitive and physical problems as in depression, with less severe but longer-lasting symptoms.

Dysphoria is a profound state of unease or dissatisfaction. In a psychiatric context, dysphoria may accompany depression, anxiety, or agitation. It can also refer to a state of not being comfortable in one's current body, particularly in cases of gender dysphoria. Common reactions to dysphoria include emotional distress, in some cases, even physical distress is seen. The opposite state of mind is known as euphoria.

Rumination is the focused attention on the symptoms of one's distress, and on its possible causes and consequences, as opposed to its solutions.

Melancholic Depression is a subtype of clinical depression requiring at least one of the following symptoms: Anhedonia (the inability to find pleasure in positive things). Lack of mood reactivity (i.e. mood does not improve in response to positive events). And at least three of the following: Depression that is subjectively different from grief or loss. Severe weight loss or loss of appetite. Psychomotor agitation or retardation. Early morning awakening. Guilt that is excessive. Worse mood in the morning.

Bipolar also known as manic depression, is a mental disorder that causes periods of depression and periods of elevated mood. The elevated mood is significant and is known as mania or hypomania, depending on its severity, or whether symptoms of psychosis are present. During mania, an individual behaves or feels abnormally energetic, happy, or irritable. Individuals often make poorly thought out decisions with little regard to the consequences. The need for sleep is usually reduced during manic phases. During periods of depression, there may be crying, a negative outlook on life, and poor eye contact with others.

Masked Depression was a proposed form of atypical depression in which somatic symptoms or behavioural disturbances dominate the clinical picture and disguise the underlying affective disorder.

is characteristic of the body as opposed to the mind or spirit.

Atypical Depression is characterized by improved mood in response to positive events. In contrast, people with melancholic depression generally do not experience an improved mood in response to normally pleasurable events. Atypical depression also features significant weight gain or an increased appetite, hypersomnia, a heavy sensation in the limbs and interpersonal rejection sensitivity that results in significant social or occupational impairment.

Malaise is a feeling of general discomfort, uneasiness or pain, often the first indication of an infection or other disease.

Melancholia a disease or ailment being caused by an imbalance in one or other of the four basic bodily liquids, or humours, black bile, yellow bile, phlegm and blood. Humorism was a system of medicine detailing the makeup and workings of the human body, adopted by Ancient Greek and Roman physicians and philosophers, positing that an excess or deficiency of any of four distinct bodily fluids in a person—known as humors or humours—directly influences their temperament and health. It is also present in the Indian Ayurveda system of medicine.

Psychosomatic Medicine is when mental processes act as a major factor affecting medical outcomes are areas where psychosomatic medicine has competence.

Late Life Depression refers to a major depressive episode occurring for the first time in an older person (usually over 50 or 60 years of age). Concurrent medical problems and lower functional expectations of elderly patients often obscure the degree of impairment. Typically, elderly patients with depression do not report depressed mood, but instead present with less specific symptoms such as insomnia, anorexia, and fatigue. Elderly persons sometimes dismiss less severe depression as an acceptable response to life stress or a normal part of aging, which it is not.

Major Depression With Seasonal Variation, Is It a Valid Construct?
Epidemiologic Depression Scale
Creative Healing Online

Don't be a Debbie Downer, be a Pollyanna instead.

Visceral is obtained through intuition rather than from reasoning or observation.

Boredom does not exist. You either forgot what you are doing or you are unaware of your options and capabilities.

Anhedonia is the inability to enjoy things or feel excitement or experience pleasure from activities usually found enjoyable.

"Regularly use of the Internet can have a 33 percent reduction in depression, that's if you use it right."

GLYX-13 is a novel antidepressant that is under development by Allergan (previously Naurex) as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder.

Rhodiola Rosea is a perennial flowering plant in the family Crassulaceae, has been used for centuries to cope with the cold Siberian climate and stressful life. The plant has been used in traditional Chinese medicine, where it is called hóng jǐng tiān. The medicine can be used to prevent altitude sickness. The herb may be helpful for enhancing physical performance and alleviating mental fatigue, methodological flaws limit accurate assessment of efficacy. (commonly golden root, rose root, roseroot, western roseroot, Aaron's rod, Arctic root, king's crown, lignum rhodium, orpin rose).

Two of the neurochemicals that have an important role in mental health, particularly anxiety and depression, are glutamate and gamma-aminobutyric acid or ‘GABA’ for short. Elevated levels of glutamate have been found in the brains of people with depression, specifically in the basal ganglia, an area that has a key role in motor control, motivation and decision-making. High levels of glutamate in this part of the brain have been associated with anhedonia (an inability to experience pleasure), and slow motor function. When glutamate is too high, it can become toxic to neurons and glia (the cells that make sure the brain stays healthy). There is extensive research evidence that supports the relationship between systemic inflammation and depression. People with depression have all the primary markers of systemic inflammation (caused by stress, diet, toxins, allergies, illness). Researchers now think that one of the ways that inflammation may do this is by increasing glutamate levels in critical areas of the brain.

Neurochemistry - Neurochemical

The role of inflammation in depression: from evolutionary imperative to modern treatment target

Towards a Glutamate Hypothesis of Depression

Both Physical Exercise and Progressive Muscle Relaxation Reduce the Facing-the-Viewer Bias in Biological Motion Perception - Body Smart

Depression Linked to Reduced Arginine Levels

Arginine is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group, an α-carboxylic acid group, and a side chain consisting of a 3-carbon aliphatic straight chain ending in a guanidino group.a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. Preterm infants are unable to synthesize or create arginine internally, making the amino acid nutritionally essential for them. Most healthy people do not need to supplement with arginine because it is a component of all protein-containing foods and can be synthesized in the body from glutamine via citrulline. Arginine plays an important role in cell division, wound healing, removing ammonia from the body, immune function, and the release of hormones. It is a precursor for the synthesis of nitric oxide (NO), making it important in the regulation of blood pressure. L-arginine is generally recognized as safe (GRAS-status) at intakes of up to 20 grams per day.

How taking Pain killers like Paracetamol can reduce empathy in a person.

We have learned a lot about how our human chemistry and how it can affected by our environment, and by the choices that we make. We have learned that the human body needs maintenance in order for it to maximize its physical abilities. Some of this maintenance includes Proper Sleep, Proper Food, Proper Exercise and Avoiding Allergies and sensitivities from the environment. To me depression is a Chemical Reaction, or information in the brain, that is misinterpreted, which makes your thoughts difficult to control and not easy to understand. Don't confuse Apathy or Annoyance with Depression, because being Cranky could just be from a lack of Sleep. And you also don't want to confuse Grief and Disappointment with Depression either because those feelings should only be temporary. We have learned to never underestimate the importance of this human responsibility of maintaining a healthy and strong body. The main reason being that proper exercise and proper food intake also controls the human chemistry that we depend on to work properly. And we need to understand as much as we can about our human chemistry if we are to recognize when things are not correct. Reoccurring concerns that we experience are questions that we need to answer completely or they will continue to show up in our thought processes. So again Problem Solving Skills show us just how important these skills are to have and how they can be applied to almost every area of our lives. Our Relationships with other people can also have both positive and negative impacts on our chemistry. When these impacts are negative, these types of stresses can cause confusion in our human chemistry. But just being physically strong will not guarantee that you will not struggle with your emotions or recognize when your thinking has become impaired. You need to be knowledgeable about the abilities of the Human Brain. You have to determine which chemical imbalances are accurate and which chemical signals are inaccurate. We do this by asking the right questions and by analyzing the right areas of our body. You need to look at all the influences before you decide on what changes to make and when to make them. Be very cautious when it comes to Medications because you may just be treating the symptoms and not the cause, which in the long run could make your depression worse. Be Very Careful when Experimenting with Drugs, especially Pharmaceuticals.  There's a difference between Worrying, Anxieties and Depression?

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA Receptor expression in a mouse via the vagus nerve.

Lactobacillus Acidophilus is a species of gram positive bacteria in the genus Lactobacillus. L. acidophilus is a homofermentative, microaerophilic species, fermenting sugars into lactic acid, and grows readily at rather low pH values (below pH 5.0) and has an optimum growth temperature of around 37 °C (99 °F). L. acidophilus occurs naturally in the human and animal gastrointestinal tract and mouth. Some strains of L. acidophilus may be considered to have Probiotic characteristics. These strains are commercially used in many dairy products, sometimes together with Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus in the production of acidophilus-type yogurt. Its genome has been sequenced.


A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. What do you say to someone who's depressed? Tell them.."I'm Here For You, how can I help?" Tell them.."Let's Do Something, lets take a walk, lets talk to someone, let's go somewhere nice. Tell them...I Don't Know Exactly What You're Feeling, But It Has To Be Hard. Try not to talk, listen carefully to the person. Don't give stupid advice or say stupid things. Like don't worry you'll get better, or, don't feel bad because there are people who have it worse then you.

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

What therapists should do

If sadness is created by me, then sadness does not exist, and hopelessness does not exist. Perspective should be based on correct calculations of the facts, but I'm not always aware of all the math that's involved. So what ever I'm feeling is not exactly accurate. And as soon I start checking for accuracy, I find out that the sadness was misrepresented, so my feeling of hopelessness was just a feeling, and not based on any facts. So I have no proof that things are hopeless. So the fact is, you can't prove things are hopeless, because once you start trying to calculate its existence, it's gone. And that is mostly because possibilities are every where. So I either forgot that the possibilities were there, or I never took the time to look for them, always take time to look.

System Reboot

Be extremely careful, don't relate yourself to a word that describes a feeling of very little importance, something that is vague, something that cannot be accurately interpreted.

The sun shines even on cloudy days, so when life hands you lemons, you make lemonade.   Life Quotes

Onism is false, irrelevant and narrow minded. To see the world from only your experience is to see very little, and to know very little. Besides, some experiences are better to read about then they are to physically experience yourself. You can't do it all, you can't do everything and you can't know everything. But together, we can do everything, and we can know everything. Though we are individuals, we are still one, one unique species, among millions of other species. We are part of a growing universe, part of a growing galaxy, part of a growing world. Our future ahead of us stretches billions of years. We have created more experiences in the last 100 years then we have in our entire existence here on earth. Does it mean we need to experience them all? No. Does it mean we need to see it all? No. Does it mean we need to know it all? No. Do as much as you can, learn as much as you can, share as much as you can and enjoy as much as you can. Leave the sorrow and self pity with the ignorance from which it came. We have no time for sadness, or ignorant points of view that are based on misconceptions and narrow mindedness.

Related Subject Pages
What is Life?
Controls - Confidence
Happiness - Positive Thinking
Meditation - Therapy
Trauma - Suicide - Stress - Grieving
Intelligence - Inspiration
Self Smart - People Smart
Behavior - Anger - Sanity

Live, Learn, Love and Progress...Let's get on with this..

As a child I just loved to ride my bike, it was one of the greatest things that I learned as a kid. But once you stop enjoying something that you have done your whole life, you have to wonder what happened? Why are you not having fun anymore doing this activity? Riding a bike and other sports have always had some discomfort, but that never stopped you from enjoying the experience before, never, so what is it? Did you forgot how amazing riding your bike is? When we forget to live in the moments that make up our life, and when we forget how to enjoy those moments, that's when we start to lose the enjoyment of life. Live, Learn, Love and Progress.

The Thinker Man